(S)-3-Hydroxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
(S)-1-FMOC-3-Pyrrolidinol
CAS: 215178-38-4
Molecular Formula: C19H19NO3
(S)-3-Hydroxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester - Names and Identifiers
| Name | (S)-1-FMOC-3-Pyrrolidinol |
| Synonyms | (S)-1-FMOC-3-Pyrrolidinol 1-FMOC-3-HYDROXY-PYRROLIDINE (S)-1-FMOC-3-hydroxypyrrolidine (S)-1-(9-Fluorenylmethyloxycarbonyl)-3-hydroxypyrrolidine (S)-1-(9-Fluorenylmethyloxycarbonyl)-3-hydroxypyrrolidine 9H-fluoren-9-ylmethyl (3S)-3-hydroxypyrrolidine-1-carboxylate 9H-fluoren-9-ylMethyl (3S)-3-hydroxypyrrolidine-1-carboxylate 3-hydroxy-1-pyrrolidinecarboxylic acid 9H-fluoren-9-ylmethyl ester (S)-3-Hydroxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 1-Pyrrolidinecarboxylic acid, 3-hydroxy-, 9H-fluoren-9-ylmethyl ester, (3S)- |
| CAS | 215178-38-4 |
| InChI | InChI=1/C19H19NO3/c21-13-9-10-20(11-13)19(22)23-12-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18/h1-8,13,18,21H,9-12H2/t13-/m0/s1 |
(S)-3-Hydroxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester - Physico-chemical Properties
| Molecular Formula | C19H19NO3 |
| Molar Mass | 309.36 |
| Density | 1.295g/cm3 |
| Melting Point | 106-110 °C (dec.) |
| Boling Point | 496.1°C at 760 mmHg |
| Flash Point | 253.8°C |
| Vapor Presure | 1.17E-10mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.643 |
(S)-3-Hydroxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29339900 |
(S)-3-Hydroxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester - Introduction
(S)-1-FMOC-3-Pyrrolidinol, also known as (S)-1-FMOC-3-Pyrrolidinol, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
(S)-1-fmoc-3-yrrolidinol is a colorless to pale yellow crystal with a special odor. Its chemical formula is C17H17NO3 and its molecular weight is 287.32. It is a chiral compound that is optically active and usually exists as the (S)-enantiomer.
Use:
(S)-1-fmoc-3-yrrolidinol is commonly used as protecting group, chiral inducer and chiral catalyst in organic synthesis. As a protecting group, it can protect some functional groups such as amino and hydroxyl in order to avoid unnecessary chemical reactions in the reaction. In addition, it can also be used as a raw material for the synthesis of chiral compounds, and is widely used in natural product synthesis and drug synthesis.
Method:
The preparation method of (S)-1-FMOC-3-Pyrrolidinol is relatively complicated. A common method is to combine (S)-Buthanol with FMOC-Cl(2,2,4,6, 7-pentafluoro-3-methyl-4-oxo-1, 3-dioxane-5-enoic acid chloro ester) reacts under basic conditions to obtain the target compound.
Safety Information:
(S)-1-fmoc-3-pirrolidinol is relatively safe under general operating conditions, but the following matters still need to be paid attention to: its dust may irritate the eyes and skin, rinse with plenty of water immediately after contact. Operate in a well-ventilated area and wear appropriate personal protective equipment such as lab gloves and goggles. At the same time, during handling and storage, avoid contact with oxidants and heat sources to avoid fire and explosion.
Nature:
(S)-1-fmoc-3-yrrolidinol is a colorless to pale yellow crystal with a special odor. Its chemical formula is C17H17NO3 and its molecular weight is 287.32. It is a chiral compound that is optically active and usually exists as the (S)-enantiomer.
Use:
(S)-1-fmoc-3-yrrolidinol is commonly used as protecting group, chiral inducer and chiral catalyst in organic synthesis. As a protecting group, it can protect some functional groups such as amino and hydroxyl in order to avoid unnecessary chemical reactions in the reaction. In addition, it can also be used as a raw material for the synthesis of chiral compounds, and is widely used in natural product synthesis and drug synthesis.
Method:
The preparation method of (S)-1-FMOC-3-Pyrrolidinol is relatively complicated. A common method is to combine (S)-Buthanol with FMOC-Cl(2,2,4,6, 7-pentafluoro-3-methyl-4-oxo-1, 3-dioxane-5-enoic acid chloro ester) reacts under basic conditions to obtain the target compound.
Safety Information:
(S)-1-fmoc-3-pirrolidinol is relatively safe under general operating conditions, but the following matters still need to be paid attention to: its dust may irritate the eyes and skin, rinse with plenty of water immediately after contact. Operate in a well-ventilated area and wear appropriate personal protective equipment such as lab gloves and goggles. At the same time, during handling and storage, avoid contact with oxidants and heat sources to avoid fire and explosion.
Last Update：2024-04-09 21:11:58
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CAS: 215178-38-4
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CAS: 215178-38-4
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